New CRISPR-Cas systems from uncultivated microbes.

David Burstein==Lucas B. Harrington==Steven C. Strutt==Alexander J. Probst==Karthik Anantharaman==Brian C. Thomas==Jennifer A. Doudna==Jillian F. Banfield==

摘要(来源:Pubmed Central):

CRISPR-Cas systems provide microbes with adaptive immunity by employing short sequences, termed spacers, that guide Cas proteins to cleave foreign DNA1,2. Class 2 CRISPR-Cas systems are streamlined versions in which a single Cas protein ...