A coprocessor architecture for fast protein structure prediction

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摘要

Predicting the protein structure from an amino acid sequence is computationally very intensive. In order to speed up protein sequence matching and processing, we present a novel coprocessor architecture for fast protein structure prediction. The architecture consists of systolic arrays to speed up the data intensive sequence alignment and structure prediction steps, and finite state machines for the control dominated steps. The architecture has been synthesized using Synopsys DC Compiler in 0.18 micron CMOS technology and details of its area and timing performance have been provided. A procedure to develop architectures with area-time trade-offs has also been presented.

论文关键词:Protein structure prediction,PSIPRED,PSI BLAST,Neural network,VLSI architecture

论文评审过程:Received 1 September 2005, Revised 9 December 2005, Accepted 12 December 2005, Available online 31 January 2006.

论文官网地址:https://doi.org/10.1016/j.patcog.2005.12.006