Automated segmentation of overlapped nuclei using concave point detection and segment grouping

作者：

Highlights：

• Level set method is proposed to extract contours and evaluate whether a nucleus is blurry.

• A novel concave point detection method is proposed to detect obvious and unobvious concave point.

• A simple but efficient algorithm is proposed to set contour segments into groups is proposed.

• The proposed method reaches a high accuracy in both clear and blurry nucleus.

摘要

•Level set method is proposed to extract contours and evaluate whether a nucleus is blurry.•A novel concave point detection method is proposed to detect obvious and unobvious concave point.•A simple but efficient algorithm is proposed to set contour segments into groups is proposed.•The proposed method reaches a high accuracy in both clear and blurry nucleus.

论文关键词：Nuclei segmentation,Concave point detection,Contour grouping,Ellipse fitting

论文评审过程：Received 18 November 2016, Revised 19 May 2017, Accepted 11 June 2017, Available online 13 June 2017, Version of Record 21 June 2017.

论文官网地址：https://doi.org/10.1016/j.patcog.2017.06.021