A nosocomial-pathogens-infections model with impulsive antibiotics treatment on multiple bacteria

作者：

Highlights：

• A nosocomial-pathogens-infections model with therapy on multiple bacteria is studied.

• Sufficient conditions for treatment success and treatment failure are obtained.

• Different cases for antibiotic treatment resistance are discussed.

• Our study indicates more effective therapeutic regimen for nosocomial infection.

摘要

•A nosocomial-pathogens-infections model with therapy on multiple bacteria is studied.•Sufficient conditions for treatment success and treatment failure are obtained.•Different cases for antibiotic treatment resistance are discussed.•Our study indicates more effective therapeutic regimen for nosocomial infection.

论文关键词：Antibiotic therapy,Wild-type and resistant bacteria,Erythromycin–Vancomycin,Impulsive input,Basic reproduction ratio,Persistence

论文评审过程：Received 29 October 2015, Revised 12 September 2016, Accepted 7 October 2016, Available online 26 October 2016, Version of Record 26 October 2016.

论文官网地址：https://doi.org/10.1016/j.amc.2016.10.013