Exogenous re-infection does not always cause backward bifurcation in TB transmission dynamics
作者：
Highlights：
• Exogenous re-infection does not always cause backward bifurcation in TB transmission dynamics.
• Backward bifurcation in TB disease is more likely to occur if (a) the rates of re-infection and transmissibility of re-infected individuals are sufficiently high (b) the fraction of slow progressors is increased or if the rates of treatment and disease-induced mortality are increased.
• Backward bifurcation in TB disease is less likely to occur for increasing rate of endogenous re-activation of latent TB cases.
摘要
•Exogenous re-infection does not always cause backward bifurcation in TB transmission dynamics.•Backward bifurcation in TB disease is more likely to occur if (a) the rates of re-infection and transmissibility of re-infected individuals are sufficiently high (b) the fraction of slow progressors is increased or if the rates of treatment and disease-induced mortality are increased.•Backward bifurcation in TB disease is less likely to occur for increasing rate of endogenous re-activation of latent TB cases.
论文关键词：Backward bifurcation,Equilibria,Mycobacterium tuberculosis,Reproduction number,Re-infection,Stability
论文评审过程：Received 31 May 2016, Revised 6 September 2016, Accepted 14 November 2016, Available online 5 December 2016, Version of Record 5 December 2016.
论文官网地址：https://doi.org/10.1016/j.amc.2016.11.009
