Mathematical model of an antiretroviral therapy to HIV via Filippov theory
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This work aims to study some qualitative features of piecewise smooth systems applied to the dynamics of the Human Immunodeficiency Virus (HIV). The application of sliding mode control and strategies of structured treatment interruptions in HIV is a new and challenging research area, which deserves attention and improvement. We investigate the dynamic behavior of the discontinuous mathematical model and we observe the occurrence of typical singularities.
论文关键词:HIV,Piecewise smooth vector fields,Typical singularities,Antiretroviral therapies,Intermittent treatment
论文评审过程:Received 1 April 2019, Revised 6 January 2020, Accepted 23 February 2020, Available online 13 March 2020, Version of Record 2 September 2020.
论文官网地址:https://doi.org/10.1016/j.amc.2020.125179