Centrality analysis in a drug network and its application to drug repositioning

作者：

Highlights：

• A novel application of centrality in a drug network is presented.

• A centrality-guided approach for predicting drug repositioning candidates is proposed.

• Topological advantages associated with central network positions of drugs may be translated into potential clinical benefits.

• Significance of network centrality measures in drug development is discussed.

摘要

•A novel application of centrality in a drug network is presented.•A centrality-guided approach for predicting drug repositioning candidates is proposed.•Topological advantages associated with central network positions of drugs may be translated into potential clinical benefits.•Significance of network centrality measures in drug development is discussed.

论文关键词：Network analysis,Centrality,Network application,Drug networks,Drug repositioning

论文评审过程：Received 17 September 2020, Revised 27 November 2020, Accepted 3 December 2020, Available online 19 December 2020, Version of Record 19 December 2020.

论文官网地址：https://doi.org/10.1016/j.amc.2020.125870