Modelling the dynamics of antimicrobial-resistant typhoid infection with environmental transmission

作者：

Highlights：

• A two-strain typhoid model with direct and environmental transmissions was developed.

• Even if R0dir<1, typhoid invasion is possible with environmental transmission.

• Sensitive strain alone does not exist with treatment-induced acquired resistance.

• Treatment-induced acquired resistance enhances the co-existence of the two strains.

• Resistant strain alone with lower transmissibility can persist due to re-infection.

摘要

•A two-strain typhoid model with direct and environmental transmissions was developed.•Even if R0dir<1, typhoid invasion is possible with environmental transmission.•Sensitive strain alone does not exist with treatment-induced acquired resistance.•Treatment-induced acquired resistance enhances the co-existence of the two strains.•Resistant strain alone with lower transmissibility can persist due to re-infection.

论文关键词：Salmonella enterica serovar Typhi,Treatment-induced acquired resistance,Stability,Re-infection

论文评审过程：Received 12 August 2020, Revised 6 December 2020, Accepted 4 February 2021, Available online 22 February 2021, Version of Record 22 February 2021.

论文官网地址：https://doi.org/10.1016/j.amc.2021.126081