Uncertain pharmacokinetic model based on uncertain differential equation

作者：

Highlights：

• Propose an uncertain pharmacokinetic model for mono-compartmental drugs administered with intravenous administration.

• Investigate several essential pharmacokinetic indexes.

• Present a paradox of the stochastic pharmacokinetic model.

摘要

•Propose an uncertain pharmacokinetic model for mono-compartmental drugs administered with intravenous administration.•Investigate several essential pharmacokinetic indexes.•Present a paradox of the stochastic pharmacokinetic model.

论文关键词：Uncertain pharmacokinetic model,Uncertain differential equation,First order kinetics,Parameter estimations,Confidence interval

论文评审过程：Received 26 January 2020, Revised 11 January 2021, Accepted 16 February 2021, Available online 6 April 2021, Version of Record 6 April 2021.

论文官网地址：https://doi.org/10.1016/j.amc.2021.126118