Mathematical modeling of glioma invasion: acid- and vasculature mediated go-or-grow dichotomy and the influence of tissue anisotropy

作者：

Highlights：

• Multiscale modeling for acid- and vasculature mediated glioma invasion.

• Effects of go-or-grow dichotomy and tissue anisotropy.

• Deduction of effective macroscopic equations for glioma and vasculature.

• Macroscopic PDEs with multiple taxis towards/away from environmental signals.

• Numerical simulations and necrosis-based tumor grading.

摘要

•Multiscale modeling for acid- and vasculature mediated glioma invasion.•Effects of go-or-grow dichotomy and tissue anisotropy.•Deduction of effective macroscopic equations for glioma and vasculature.•Macroscopic PDEs with multiple taxis towards/away from environmental signals.•Numerical simulations and necrosis-based tumor grading.

论文关键词：Multiscale modeling of glioma invasion,Go-or-grow dichotomy and hypoxia-driven phenotypic switch,Multiple taxis,Necrosis-based tumor grading

论文评审过程：Received 23 October 2020, Revised 31 March 2021, Accepted 25 April 2021, Available online 19 May 2021, Version of Record 19 May 2021.

论文官网地址：https://doi.org/10.1016/j.amc.2021.126305