Dynamic analysis of synaptic loss and synaptic compensation in the process of associative memory ability decline in Alzheimer’s disease

作者：

Highlights：

• By establishing a neural network spiking model with multiple associative memories, the pathogenesis of AD is analyzed from the perspective of associative memories.

• To simulate the different stages of AD, a synaptic loss model is established which determines the stages of AD through associative memory ability.

• In order to seek for the treatment of AD, a synaptic compensation model is established on the basis of the synaptic loss model to study the recovery of associative memory ability of the neural network under different stages of compensation intensity.

摘要

•By establishing a neural network spiking model with multiple associative memories, the pathogenesis of AD is analyzed from the perspective of associative memories.•To simulate the different stages of AD, a synaptic loss model is established which determines the stages of AD through associative memory ability.•In order to seek for the treatment of AD, a synaptic compensation model is established on the basis of the synaptic loss model to study the recovery of associative memory ability of the neural network under different stages of compensation intensity.

论文关键词：Associative memory neural network,Synaptic plasticity,Synapse loss,Synapse compensation

论文评审过程：Received 29 March 2021, Revised 9 May 2021, Accepted 13 May 2021, Available online 2 June 2021, Version of Record 2 June 2021.

论文官网地址：https://doi.org/10.1016/j.amc.2021.126372