Multi-level medical knowledge formalization to support medical practice for chronic diseases

作者：

Highlights：

• Comparison of formal languages for procedural knowledge representation is provided.

• An intuitive and effective mechanism of medical knowledge formalization is proposed.

• A methodology to model medical procedures from individual, multi-level, medical processes is proposed.

• Extended Timed Transition Diagram represents three basic levels of decision-making.

• Models of therapeutic strategy, drug titration, and drug intolerances are obtained.

摘要

•Comparison of formal languages for procedural knowledge representation is provided.•An intuitive and effective mechanism of medical knowledge formalization is proposed.•A methodology to model medical procedures from individual, multi-level, medical processes is proposed.•Extended Timed Transition Diagram represents three basic levels of decision-making.•Models of therapeutic strategy, drug titration, and drug intolerances are obtained.

论文关键词：Knowledge representation,Decision-making,Medical processes,Procedural knowledge modeling,Knowledge-based framework,Medical decision support

论文评审过程：Received 21 December 2016, Revised 20 November 2018, Accepted 8 December 2018, Available online 15 December 2018, Version of Record 27 February 2019.

论文官网地址：https://doi.org/10.1016/j.datak.2018.12.001