The IFAST model, a novel parallel nonlinear EEG analysis technique, distinguishes mild cognitive impairment and Alzheimer's disease patients with high degree of accuracy

摘要

ObjectiveThis paper presents the results obtained with the innovative use of special types of artificial neural networks (ANNs) assembled in a novel methodology named IFAST (implicit function as squashing time) capable of compressing the temporal sequence of electroencephalographic (EEG) data into spatial invariants. The aim of this study is to assess the potential of this parallel and nonlinear EEG analysis technique in distinguishing between subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients with a high degree of accuracy in comparison with standard and advanced nonlinear techniques. The principal aim of the study was testing the hypothesis that automatic classification of MCI and AD subjects can be reasonably correct when the spatial content of the EEG voltage is properly extracted by ANNs.