Bridge and brick network motifs: Identifying significant building blocks from complex biological systems

摘要

ObjectiveA major focus in computational system biology research is defining organizing principles that govern complex biological network formation and evolution. The task is considered a major challenge because network behavior and function prediction requires the identification of functionally and statistically important motifs. Here we propose an algorithm for performing two tasks simultaneously: (a) detecting global statistical features and local connection structures in biological networks, and (b) locating functionally and statistically significant network motifs.