A new multiple regression approach for the construction of genetic regulatory networks
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摘要
ObjectiveRe-construction of a genetic regulatory network from a given time-series gene expression data is an important research topic in systems biology. One of the main difficulties in building a genetic regulatory network lies in the fact that practical data set has a huge number of genes vs. a small number of sampling time points. In this paper, we propose a new linear regression model that may overcome this difficulty for uncovering the regulatory relationship in a genetic network.
论文关键词：Gene regulatory network,Multiple regression,Power-law,Statistical tests
论文评审过程：Received 12 August 2008, Revised 4 September 2009, Accepted 8 September 2009, Available online 5 December 2009.
论文官网地址：https://doi.org/10.1016/j.artmed.2009.11.001
