Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival
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摘要
ObjectiveSmoking is a prominent risk factor for lung cancer. However, it is not an established prognostic factor for lung cancer in clinics. To date, no gene test is available for diagnostic screening of lung cancer risk or prognostication of clinical outcome in smokers. This study sought to identify a smoking associated gene signature in order to provide a more precise diagnosis and prognosis of lung cancer in smokers.
论文关键词：Implication networks based on prediction logic,Gene coexpression networks based on formal logic,Smoking,Gene signature,Lung cancer diagnosis and prognosis,Signaling pathways
论文评审过程：Received 6 July 2011, Revised 7 November 2011, Accepted 17 January 2012, Available online 11 February 2012.
论文官网地址：https://doi.org/10.1016/j.artmed.2012.01.001
