Differential regulation analysis reveals dysfunctional regulatory mechanism involving transcription factors and microRNAs in gastric carcinogenesis

作者：

Highlights：

• The framework for exploring the differences between GRNs from multiple perspectives was established.

• An innovative strategy for identifying cancer-related regulations was proposed.

• Hypotheses of dysregulated mechanisms in gastric carcinogenesis were generated.

• The fine-tuning role of miRNAs was observed at the level of gene regulatory network.

摘要

•The framework for exploring the differences between GRNs from multiple perspectives was established.•An innovative strategy for identifying cancer-related regulations was proposed.•Hypotheses of dysregulated mechanisms in gastric carcinogenesis were generated.•The fine-tuning role of miRNAs was observed at the level of gene regulatory network.

论文关键词：Gastric cancer,Differential coexpression analysis,Differential regulation analysis,Combinatorial gene regulatory network

论文评审过程：Received 30 December 2016, Revised 23 February 2017, Accepted 23 February 2017, Available online 1 March 2017, Version of Record 15 March 2017.

论文官网地址：https://doi.org/10.1016/j.artmed.2017.02.006