Detection of protein complexes from multiple protein interaction networks using graph embedding

作者：

Highlights：

• Integrate multiple PPI datasets from different species into a single network.

• Use a graph embedding method to encode protein nodes into continuous vector spaces.

• Quantify the relations based on their corresponding node embedding similarities.

• Utilize a seed-and-extend strategy to identify protein complexes.

摘要

•Integrate multiple PPI datasets from different species into a single network.•Use a graph embedding method to encode protein nodes into continuous vector spaces.•Quantify the relations based on their corresponding node embedding similarities.•Utilize a seed-and-extend strategy to identify protein complexes.

论文关键词：Network embedding,Protein complex identification,Protein–protein interaction networks

论文评审过程：Received 22 March 2018, Revised 6 April 2019, Accepted 6 April 2019, Available online 9 April 2019, Version of Record 16 April 2019.

论文官网地址：https://doi.org/10.1016/j.artmed.2019.04.001