Modelling and assessing one- and two-drug dose titrations

作者：

Highlights：

• Proposed graphical language is used to formalize standard dose titration procedural units.

• Formalization of one- and two-drug titration procedures of chronic and acute cases is proposed.

• A combination of the proposed dose titration procedural units are capable of representing various dose adjustment procedures.

• Proposed dose titration models are capable of detecting common medical errors in the titration procedures.

摘要

•Proposed graphical language is used to formalize standard dose titration procedural units.•Formalization of one- and two-drug titration procedures of chronic and acute cases is proposed.•A combination of the proposed dose titration procedural units are capable of representing various dose adjustment procedures.•Proposed dose titration models are capable of detecting common medical errors in the titration procedures.

论文关键词：Drug dose titration,Medication errors,Knowledge representation,Evidence-based medicine

论文评审过程：Received 24 December 2021, Revised 6 May 2022, Accepted 27 June 2022, Available online 2 July 2022, Version of Record 13 July 2022.

论文官网地址：https://doi.org/10.1016/j.artmed.2022.102343