Discovery of functional protein groups by clustering community links and integration of ontological knowledge

作者:

Highlights:

• Protein-to-protein interactions constitute a major element of biology.

• We use ontologies as a useful source of structured knowledge.

• Clustering the links shared by proteins reveals their shared/multiple function nature.

• Combining link clustering with databases, provides a deeper insight into protein function.

摘要

•Protein-to-protein interactions constitute a major element of biology.•We use ontologies as a useful source of structured knowledge.•Clustering the links shared by proteins reveals their shared/multiple function nature.•Combining link clustering with databases, provides a deeper insight into protein function.

论文关键词:Cystinosis,Protein-to-protein interactions,Clustering,Ontologies

论文评审过程:Available online 25 March 2013.

论文官网地址:https://doi.org/10.1016/j.eswa.2013.03.027