A cluster-DEE-based strategy to empower protein design

作者：

Highlights：

• Clustering and DEE techniques are combined with a SAT problem representation of the CPD problem.

• A knowledge-based method is combined with an ab initio strategy.

• Integrated Artificial Intelligence techniques are useful tools for the CPD problem.

• The proposed method was tested with eight protein sequences.

• Analysis reveal that the proposed method presents accurate results.

摘要

•Clustering and DEE techniques are combined with a SAT problem representation of the CPD problem.•A knowledge-based method is combined with an ab initio strategy.•Integrated Artificial Intelligence techniques are useful tools for the CPD problem.•The proposed method was tested with eight protein sequences.•Analysis reveal that the proposed method presents accurate results.

论文关键词：Integrated intelligent methods,Protein design,Structural bioinformatics,Clustering algorithms,Boolean Satisfiability problem,Dead-End-Elimination

论文评审过程：Available online 18 March 2013.

论文官网地址：https://doi.org/10.1016/j.eswa.2013.03.011