The confounding role of common diabetes medications in developing acute renal failure: A data mining approach with emphasis on drug-drug interactions

作者:

Highlights:

• An extent data mining approach is extended to assess the confounding role of drugs.

• General confounding role of diabetes drugs in developing renal failure is identified.

• Potential drug-drug interactions significantly modify the confounding role of drugs.

• Findings explain the inconsistent effects of diabetes drugs reported in prior research.

摘要

•An extent data mining approach is extended to assess the confounding role of drugs.•General confounding role of diabetes drugs in developing renal failure is identified.•Potential drug-drug interactions significantly modify the confounding role of drugs.•Findings explain the inconsistent effects of diabetes drugs reported in prior research.

论文关键词:Adverse drug reactions,Itemset mining,Diabetes,Acute renal failure,Drug-drug interactions

论文评审过程:Received 5 September 2018, Revised 2 January 2019, Accepted 3 January 2019, Available online 10 January 2019, Version of Record 19 January 2019.

论文官网地址:https://doi.org/10.1016/j.eswa.2019.01.006