Computing Information in Neuronal Spikes

摘要

This paper provides new insights regarding the transfer of information between input signal and the output of neurons. Simulations of the Hodgkin-Huxley (HH) model combined with computational techniques are used to estimate this transfer of information. Our analysis shows that comparatively, mutual information (MI) between input signal and sodium flux is about two times that between input signal and output spikes during each spike within a millisecond-level time domain. This higher transfer of information provided by ionic fluxes extends the working frequency domain of neural cells beyond those accessible to information transfer within spikes alone.