Trajectory analysis of drug-research trends in pancreatic cancer on PubMed and ClinicalTrials.gov
作者：
Highlights：
• This study is to understand the comprehensive portrait of pancreatic cancer drug research by analyzing the anti-cancer drugs mentioned in scholarly publications and clinical trials.
• We conduct drug cluster analysis using a topic modeling technique and trace the changes of drug targets by target-drug network analysis.
• Comparison of two distinct datasets gives an insight into identifying the different drug research trends and statistical analysis confirms the difference in drug research trends of these two datasets.
摘要
•This study is to understand the comprehensive portrait of pancreatic cancer drug research by analyzing the anti-cancer drugs mentioned in scholarly publications and clinical trials.•We conduct drug cluster analysis using a topic modeling technique and trace the changes of drug targets by target-drug network analysis.•Comparison of two distinct datasets gives an insight into identifying the different drug research trends and statistical analysis confirms the difference in drug research trends of these two datasets.
论文关键词：Pancreatic cancer,Text mining,Bibliometric analysis,Data analysis,Information extraction
论文评审过程：Received 1 September 2015, Revised 9 January 2016, Accepted 10 January 2016, Available online 11 February 2016, Version of Record 11 February 2016.
论文官网地址：https://doi.org/10.1016/j.joi.2016.01.003
