Topology-driven trend analysis for drug discovery

作者：

Highlights：

• We propose topology analysis to identify new relationships among therapeutic groups of drugs.

• The proposed approach also helps discover new drug for autism treatment.

• The results suggest that certain drugs could be repurposed for autism treatment in the future.

• The present study sheds new light on drug discovery research.

摘要

•We propose topology analysis to identify new relationships among therapeutic groups of drugs.•The proposed approach also helps discover new drug for autism treatment.•The results suggest that certain drugs could be repurposed for autism treatment in the future.•The present study sheds new light on drug discovery research.

论文关键词：Network analysis,Literature-based discovery,Text mining

论文评审过程：Received 12 March 2018, Revised 23 July 2018, Accepted 23 July 2018, Available online 2 August 2018, Version of Record 2 August 2018.

论文官网地址：https://doi.org/10.1016/j.joi.2018.07.007