Efficient RNAi-based gene family knockdown via set cover optimization
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摘要
Objective:We address the problem of selecting an efficient set of initiator molecules (siRNAs) for RNA interference (RNAi)-based gene family knockdown experiments. Our goal is to select a minimal set of siRNAs that (a) cover a targeted gene family or a specified subset of it, (b) do not cover any untargeted genes, and (c) are individually highly effective at inducing knockdown.
论文关键词：Gene family knockdown,siRNA design,RNA interference,Minimal siRNA cover,Set cover
论文评审过程：Received 12 November 2004, Revised 6 January 2005, Accepted 12 January 2005, Available online 9 August 2005.
论文官网地址：https://doi.org/10.1016/j.artmed.2005.01.009
