Evolutionary based optimal ensemble classifiers for HIV-1 protease cleavage sites prediction

作者:

Highlights:

• Optimal ensemble framework for HIV-1 protease cleavage site prediction.

• Optimal formation of encoding-classifier pair selection by evolutionary algorithm.

• Natural selection in number of base learners and optimal data-learner mapping.

• Credibility of propsed enesmble model in cross-domain prediction.

• Experiment on benchmark data and statistical comparison with current state of art.

摘要

•Optimal ensemble framework for HIV-1 protease cleavage site prediction.•Optimal formation of encoding-classifier pair selection by evolutionary algorithm.•Natural selection in number of base learners and optimal data-learner mapping.•Credibility of propsed enesmble model in cross-domain prediction.•Experiment on benchmark data and statistical comparison with current state of art.

论文关键词:Amino acid database,Ensemble classifier,Genetic algorithm,HIV-1 protease,Protein encoding,Support vector machine

论文评审过程:Received 23 January 2018, Revised 17 April 2018, Accepted 3 May 2018, Available online 9 May 2018, Version of Record 26 May 2018.

论文官网地址:https://doi.org/10.1016/j.eswa.2018.05.003